Although exploratory, this study suggests that such association may result from a protective FMR1 AGG interspersion pattern-related effect or unknown X-chromosome-linked anomaly that likely correlates with female infertility.ī. The study revealed that the subjects who have the highest (≥26) CAG stretch depicted significantly higher serum oxytocin levels (102.1 pg/ml n = 126, p 90:10) was statistically higher in the dissimilar group (80% versus 50%), suggesting an association between allelic score and preferential XCI. The control group consists of 155 men with normal IELT (>4 min). A total of 271 patients consulting for evidence-based lifelong premature ejaculatory dysfunction were selected in this study. In this study, we investigate the combinatorial effects of trinucleotide repeats of androgen receptor and allelic variants of the 5-HTTLPR gene on sex steroids, hypophyseal hormones, sexual performance, and premature ejaculation assessment parameters among evidence-based lifelong premature ejaculation subjects. Premature ejaculation is one of the most common sexual disorders in men due to the uncontrolled modulation of spinal reflexes. Serotonin transporter 5-HTTLPR genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation Shahzad Bhatti, Haroon Latif Khan, Sana Abbas, Yousuf Latif Khan Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital, Lahore, Pakistan. The etiology of infertility remains unknown and novel genes other than y chromosome microdeletions should be identified with high throughput techniques.Ī. Our findings are consistent with the literature.Ĭonclusion: Our results are similar to the previous studies which have mostly reported a frequency of less than 10% for Y chromosome microdeletions. Among 30 cases, AZFc microdeletions were found in 18 cases (60%), AZFa microdeletions in 4 cases (13.3%), AZFb microdeletions in 1 case (3.3%), AZFa,b,c in 4 cases (13.3%), AZFb,c in 3 cases (10%). Results: Among the 396 infertile men, we determined 30 cases of Y chromosome micro- deletions (7.57%). We evaluated microdeletions of the Y-chromosome STS markers AZFa, AZFb and AZFc, ZFX/ZFY, terminal sY160 regions by using DNA Fragment analysis. Materials and Methods: In our study, 396 infertile men referred to İstanbul University- Cerrahpaşa, Cerrahpaşa Medical Faculty Department of Medical Genetics (GETAM) between 2016 to 2020 with azoospermia/severe oligospermia. The aim of this study was to establish the frequency of the Y chromosome microdeletions in Turkish infertile men who referred to our center with severe oligozoospermia and azoospermia. Y chromosome includes genes for testicular development and spermatogenesis. Objective: Y chromosome microdeletions are the leading genetic cause of male infertility and their detection is clinically relevant for appropriate genetic counseling. Frequency of Y chromosome microdeletions in Turkish infertile men: Single Center Experience Aysel KalayciYigin, Gizem Erdogan, Deniz Agirbasli, Mehmet Seven Department of Medical Genetics, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Fatih, Turkey.
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